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CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
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This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.
PLoS Comput Biol
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
I L high threshold;
I T low threshold;
Dendritic Action Potentials;
Sterratt, David ;
Groen, Martine R [martine.groen at gmail.com];
for information about:
Hippocampus CA1 pyramidal GLU cell
I L high threshold
I T low threshold
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