CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS Comput Biol 8:e1002545 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
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bpap
validation-plots
validation-plots.tex
                            
\documentclass{article}
\usepackage[left=2in,right=2in,top=0.5in,bottom=0.5in]{geometry}
\usepackage{graphicx}



\begin{document}

\begin{center}
  \textbf{Somatic injection}
\end{center}

\begin{tabular}{@{}p{0.49\linewidth}p{0.49\linewidth}@{}}
  Low proximal CaL, cvode off
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-orig-cv0-0}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-orig-cv0-1}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-orig-cv0-2} 
  &
  High proximal CaL, cvode off
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-calh-cv0-0}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-calh-cv0-1}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-calh-cv0-2} 
  \\
  Low proximal CaL, cvode on
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-orig-cv1-0}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-orig-cv1-1}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-orig-cv1-2} 
  &
  High proximal CaL, cvode on
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-calh-cv1-0}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-calh-cv1-1}
  \includegraphics[width=\linewidth]{BPAP/Soma/bpap-calh-cv1-2} 
\end{tabular}

\pagebreak[4]

\begin{center}
  \textbf{Dendrite 62 injection}
\end{center}

\begin{tabular}{@{}p{0.49\linewidth}p{0.49\linewidth}@{}}
  Low proximal CaL, cvode off
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-orig-cv0-0}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-orig-cv0-1}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-orig-cv0-2} 
  &
  High proximal CaL, cvode off
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-calh-cv0-0}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-calh-cv0-1}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-calh-cv0-2} 
  \\
  Low proximal CaL, cvode on
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-orig-cv1-0}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-orig-cv1-1}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-orig-cv1-2} 
  &
  High proximal CaL, cvode on
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-calh-cv1-0}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-calh-cv1-1}
  \includegraphics[width=\linewidth]{BPAP/Dend62/bpap-calh-cv1-2} 
\end{tabular}

\pagebreak[4]

\begin{center}
  \textbf{Dendrite 64 injection}
\end{center}

\begin{tabular}{@{}p{0.49\linewidth}p{0.49\linewidth}@{}}
  Low proximal CaL, cvode off
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-orig-cv0-0}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-orig-cv0-1}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-orig-cv0-2} 
  &
  High proximal CaL, cvode off
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-calh-cv0-0}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-calh-cv0-1}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-calh-cv0-2} 
  \\
  Low proximal CaL, cvode on
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-orig-cv1-0}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-orig-cv1-1}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-orig-cv1-2} 
  &
  High proximal CaL, cvode on
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-calh-cv1-0}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-calh-cv1-1}
  \includegraphics[width=\linewidth]{BPAP/Dend64/bpap-calh-cv1-2} 
\end{tabular}

\end{document}