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Rhesus Monkey Layer 3 Pyramidal Neurons: V1 vs PFC (Amatrudo, Weaver et al. 2012)
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Accession:
144553
Whole-cell patch-clamp recordings and high-resolution 3D morphometric analyses of layer 3 pyramidal neurons in in vitro slices of monkey primary visual cortex (V1) and dorsolateral granular prefrontal cortex (dlPFC) revealed that neurons in these two brain areas possess highly distinctive structural and functional properties. ... Three-dimensional reconstructions of V1 and dlPFC neurons were incorporated into computational models containing Hodgkin-Huxley and AMPA- and GABAA-receptor gated channels. Morphology alone largely accounted for observed passive physiological properties, but led to AP firing rates that differed more than observed empirically, and to synaptic responses that opposed empirical results. Accordingly, modeling predicts that active channel conductances differ between V1 and dlPFC neurons. The unique features of V1 and dlPFC neurons are likely fundamental determinants of area-specific network behavior. The compact electrotonic arbor and increased excitability of V1 neurons support the rapid signal integration required for early processing of visual information. The greater connectivity and dendritic complexity of dlPFC neurons likely support higher level cognitive functions including working memory and planning.
Reference:
1 .
Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI (2012) Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices.
J Neurosci
32
:13644-60
[
PubMed
]
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Neocortex;
Prefrontal cortex (PFC);
Cell Type(s):
Neocortex L2/3 pyramidal GLU cell;
Channel(s):
I N;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Electrotonus;
Conductance distributions;
Vision;
Implementer(s):
Weaver, Christina [christina.weaver at fandm.edu];
Search NeuronDB
for information about:
Neocortex L2/3 pyramidal GLU cell
;
I N
;
I K
;
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V1_PFC_ModelDB
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Figure 10 ( baseline V1 )
Figure 10 ( dlPFC )
Figure 10 ( tuned V1 )
Figure 11 V1, same gAMPA, apical )
Figure 11 ( PFC apical )
Figure 11 ( PFC basal )
Figure 11 ( V1, low gAMPA, apical )
Figure 11 ( V1, low gAMPA, basal )
Figure 11 ( V1, same gAMPA, basal )
Figure 12 ( PFC apical )
Figure 12 ( PFC basal )
Figure 12 ( V1, low gAMPA, apical )
Figure 12 ( V1, low gAMPA, basal )
Figure 12 ( V1, same gAMPA, apical )
Figure 12 ( V1, same gAMPA, basal )
Figure 9C-D ( V1 )
Figure 9C-D ( dlPFC )
