MicrocircuitDB: CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)

CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)

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Accession:144976

The model predicts possible therapeutic treatments of Alzheimers's Disease in terms of pharmacological manipulations of channels' kinetic and activation properties. The results suggest how and which mechanism can be targeted by a drug to restore the original firing conditions. The simulations reproduce somatic membrane potential in control conditions, when 90% of membrane is affected by AD (Fig.4A of the paper), and after treatment (Fig.4B of the paper).
Reference:
1 . Culmone V, Migliore M (2012) Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments. Front Comput Neurosci 6:52 [PubMed]

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Model Type:	Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Active Dendrites; Detailed Neuronal Models; Action Potentials; Aging/Alzheimer`s;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu]; Culmone, Viviana [viviana.abigail at hotmail.it];