NMDA subunit effects on Calcium and STDP (Evans et al. 2012)

 Download zip file 
Help downloading and running models
Accession:145917
Effect of NMDA subunit on spike timing dependent plasticity.
Reference:
1 . Evans RC, Morera-Herreras T, Cui Y, Du K, Sheehan T, Kotaleski JH, Venance L, Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol 8:e1002493 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): STDP; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; GabaA; Glutamate; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow; 
//30posFillin.g

str cellpath = "/cell"
setfield /data/soma overlay 1
reset

float isi = 0.005
int i
for (i=1; i<7; i=i+1)
	echo {isi}

	step 0.22 -time
	
	setfield {cellpath}/soma inject 0.65e-9 

	step {isi} -time
	
	setfield {cellpath}/secdend1/spine_1/presyn_ext z {1/{getclock 0}}
	setfield {cellpath}/secdend1/spine_2/presyn_ext z {1/{getclock 0}}

	step 1

	setfield {cellpath}/secdend1/spine_1/presyn_ext z 0
	setfield {cellpath}/secdend1/spine_2/presyn_ext z 0

	step {0.03 - {isi}} -time
	setfield {cellpath}/soma inject 0
	step {0.47-0} -time
	reset
	isi={{isi}+0.005}
end