NMDA subunit effects on Calcium and STDP (Evans et al. 2012)

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Accession:145917
Effect of NMDA subunit on spike timing dependent plasticity.
Reference:
1 . Evans RC, Morera-Herreras T, Cui Y, Du K, Sheehan T, Kotaleski JH, Venance L, Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol 8:e1002493 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): STDP; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; GabaA; Glutamate; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
//genesis
// MScell08.p 

*relative
*cartesian
*asymmetric
*lambda_warn

*set_global ELEAK -0.070
*set_global RM 1.8
*set_global CM 0.010 
*set_global EREST_ACT -0.085

*start_cell /library/tert_dend
tert_dend none 35.927 0 0 0.80
tert_dend2 . 35.927 0 0 0.80 
tert_dend3 . 35.927 0 0 0.80
tert_dend4 . 35.927 0 0 0.80
tert_dend5 . 35.927 0 0 0.80 
tert_dend6 . 35.927 0 0 0.80
tert_dend7 . 35.927 0 0 0.80 
tert_dend8 . 35.927 0 0 0.80
tert_dend9 . 35.927 0 0 0.80
tert_dend10 . 35.927 0 0 0.80
tert_dend11 . 35.927 0 0 0.80
*makeproto /library/tert_dend

*start_cell /library/sec_dend

sec_dend none 24.230 0 0 1.100
*makeproto /library/sec_dend

*start_cell /library/prim_dend

prim_dend none 20.000 0 0 2.250
*makeproto /library/prim_dend

*start_cell
*spherical
*set_compt_param RA 4
soma none 16.000 0 0 16.000

*cylindrical

*set_compt_param RA 4
*compt /library/prim_dend
primdend1 soma 20 0 0 2.25
primdend2 soma 20 0 0 2.25
primdend3 soma 20 0 0 2.25
primdend4 soma 20 0 0 2.25

*set_compt_param RA 4
*compt /library/sec_dend
secdend1 primdend1 24.23 0 0 1.1
secdend2 primdend1 24.23 0 0 1.1
secdend3 primdend2 24.23 0 0 1.1
secdend4 primdend2 24.23 0 0 1.1
secdend5 primdend3 24.23 0 0 1.1
secdend6 primdend3 24.23 0 0 1.1
secdend7 primdend4 24.23 0 0 1.1
secdend8 primdend4 24.23 0 0 1.1

*set_compt_param        RA      2
*compt /library/tert_dend
tertdend1 secdend1 35.927  0  0  0.8
tertdend2 secdend1 35.927  0  0  0.8
tertdend3 secdend2 35.927  0  0  0.8
tertdend4 secdend2 35.927  0  0  0.8
tertdend5 secdend3 35.927  0  0  0.8
tertdend6 secdend3 35.927  0  0  0.8
tertdend7 secdend4 35.927  0  0  0.8
tertdend8 secdend4 35.927  0  0  0.8
tertdend9 secdend5 35.927  0  0  0.8
tertdend10 secdend5 35.927  0  0  0.8
tertdend11 secdend6 35.927  0  0  0.8
tertdend12 secdend6 35.927  0  0  0.8
tertdend13 secdend7 35.927  0  0  0.8
tertdend14 secdend7 35.927  0  0  0.8
tertdend15 secdend8 35.927  0  0  0.8
tertdend16 secdend8 35.927  0  0  0.8