NMDA subunit effects on Calcium and STDP (Evans et al. 2012)

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Accession:145917
Effect of NMDA subunit on spike timing dependent plasticity.
Reference:
1 . Evans RC, Morera-Herreras T, Cui Y, Du K, Sheehan T, Kotaleski JH, Venance L, Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol 8:e1002493 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): STDP; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; GabaA; Glutamate; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
//genesis
/***************************		MS Model, Version 7.6	*********************
**************************** 	     SynParamsTh.g 	*********************
	Avrama Blackwell 	kblackw1@gmu.edu
	Rebekah Evans 		rcolema2@gmu.edu
	Tom Sheehan 		tsheeha2@gmu.edu	
******************************************************************************
To change synaptic parameters, change the include in MScellSpine.g
Synaptic Parameters for thalamic inputs according to Ding ... Surmeier
*****************************************************************************/

	str AMPAname = "AMPA"
	float EkAMPA = 0.0
        float AMPAtau1 = 1.1e-3
        float AMPAtau2 = 5.75e-3 
        float AMPAgmax = 0.47e-9  //Ding 2008, th-str synapses have 2/1 NMDA/AMPA ratio, so 0.47e-9 for AMPA
		
										str GABAname = "GABA"
        float GABAtau1 = 0.25e-3    // From Galarreta and Hestrin 1997 
        float GABAtau2 = 3.75e-3    //(used in Wolfs model)
        float EkGABA = -0.060
        float GABAgmax = 750e-12  //Modified Koos 2004 

	int GABA2Spine = 0                                // = 0, No GABA; 
                                                  //   1, add GABA to spine head
                                                  //   2, add GABA to spine neck
	
	int addCa2Spine = 1		// 0, no ca channels in spine, 
					//1, yes ca channels in spine (non-synaptic)
	int NMDABufferMode = 0          // 1, connect both NMDA and AMPA calcium to NMDA_buffer
                                     // 0, connect only NMDA currents to NMDA_buffer

float useAMPANMDAGHKchannels= 0  // we do not use GHK project for NMDA/AMPA

setclock 0 5e-6 //was 5e-6
        // Simulation time step (Second)       
setclock 1 2e-5        //  time step for ascii output
//setclock 1 1e-4 // time step for graphic output


// parameters for NMDA subunits


// cortex
str	    subunit = "ThDing"
float   EkNMDA   = 0
float	Kmg       = 3.57
float	NMDAtau2      = (155e-3)/2 	//thal avg for .42 NR2B and .58 NR2A.  (300e-3)/2 (NR2B) (50e-3)/2 (NR2A) 126+29 = 155
float	NMDAgmax      = 0.94e-9      //NR2A and B from (Moyner et al., 1994 figure 7)
int ghk_yesno=0

str NMDAname = {subunit}