//genesis
// CaL13_channel.g
/*************************** MS Model, Version 7.6 *********************
**************************** CaL13_channel.g *********************
Avrama Blackwell kblackw1@gmu.edu
Rebekah Evans rcolema2@gmu.edu
Tom Sheehan tsheeha2@gmu.edu
******************************************************************************
*****************************************************************************/
function create_CaL13
str chanName = "CaL13_channel"
str compPath = "/library"
int c
float x = -0.1
int xdivs = 3000
float xmin = -0.1
float xmax = 0.05
float increment ={{xmax}-{xmin}}/{xdivs}
echo "CaL13 increment:" {increment} "V"
float mPower = 2.0
float hPower = 1.0
float hTauCaL13 = 1.477e-002
float mTauCaL13 = 0.0
float mvHalfCaL13 = -33.0e-3
float mkCaL13 = -6.7e-3
float hvHalfCaL13 = -13.4e-3
float hkCaL13 = 11.9e-3
float hInfCaL13 = 0.0
float mInfCaL13 = 0.0
float theta = 0.0
float beta = 0.0
float beta_exp = 0.0
float mA = 0.0
float mB = 0.0
float surf = 0
float qFactCaL13 = 2
float gMax = 4.25e-009
pushe {compPath}
create tabchannel {chanName}
setfield {chanName} Xpower {mPower} Ypower {hPower}
call {chanName} TABCREATE X {xdivs} {xmin} {xmax}
call {chanName} TABCREATE Y {xdivs} {xmin} {xmax}
for(c = 0; c < {xdivs} + 1; c = c + 1)
/************************ Begin CaL13_mTau *********************/
//mA = 0.0398e6*(vMemb + 8.124e-3)./
// (exp((vMemb + 8.124e-3)/9.005e-3) - 1);
//mB = 0.99e3*exp(vMemb/31.4e-3);
//mTauCaL12 = 1./(mA + mB) / qFactCaL12;
theta = 0.0398e6*{ {x} + 8.124e-3}
beta = {{x} + 8.124e-3}/9.005e-3
beta_exp = {exp {beta}}
beta_exp = beta_exp - 1.0
mA = {{theta}/{beta_exp}}
beta = {{x}/31.4e-3}
beta_exp = {exp {beta}}
mB = 0.99e3*{beta_exp}
mTauCaL13 = {1.0/{mA + mB}}/{qFactCaL13}
setfield {chanName} X_A->table[{c}] {mTauCaL13}
/************************ End CaL13_mTau ***********************/
/************************ Begin CaL13_mInf *********************/
// mInfCaL13 = 1./(1 + exp((vMemb - mvHalfCaL13)/mkCaL13));
beta = {{x} - {mvHalfCaL13}}/{mkCaL13}
beta_exp = {exp {beta}} + 1.0
mInfCaL13 = 1.0/{beta_exp}
setfield {chanName} X_B->table[{c}] {mInfCaL13}
/************************ End CaL13_mInf ***********************/
/************************ Begin CaL13_hTau *********************/
// hTauCaL13 = 14.77e-3*ones(vDiv+1,1); % Already q-corrected
setfield {chanName} Y_A->table[{c}] {hTauCaL13}
/************************ End CaL13_hTau ***********************/
/************************ Begin CaL13_hInf *********************/
// hInfCaL13 = 1./(1 + exp((vMemb - hvHalfCaL13)/hkCaL13));
beta = {{x} - {hvHalfCaL13}}/{hkCaL13}
beta_exp = {exp {beta}} + 1.0
hInfCaL13 = 1.0/{beta_exp}
setfield {chanName} Y_B->table[{c}] {hInfCaL13}
/************************ End CaL13_hInf ***********************/
x = x + increment
end
tweaktau {chanName} X
tweaktau {chanName} Y
create ghk {chanName}GHK
setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM,
setfield {chanName}GHK valency 2.0
setfield {chanName}GHK T {TEMPERATURE}
setfield {chanName} Gbar {gMax*surf}
addmsg {chanName} {chanName}GHK PERMEABILITY Gk
pope
end
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