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Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
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" ... Here, we first quantified the morphological variability of branch points from two-photon images of rat CA1 pyramidal neurons. We then investigated the geometrical features affecting spike initiation, propagation, and timing with a computational model validated by glutamate uncaging experiments. The results suggest that even subtle membrane readjustments at branch point could drastically alter the ability of synaptic input to generate, propagate, and time action potentials."
Ferrante M, Migliore M, Ascoli GA (2013) Functional impact of dendritic branch-point morphology.
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Hippocampus CA1 pyramidal GLU cell;
Action Potential Initiation;
Dendritic Action Potentials;
Influence of Dendritic Geometry;
Ferrante, Michele [mferr133 at bu.edu];
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Hippocampus CA1 pyramidal GLU cell
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