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CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
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Accession:
148646
" ... the investigation of AP backpropagation and its functional roles has greatly benefitted from computational models that use biophysically and morphologically accurate implementations. ..." This model entry recreates figures 2 and 4 from the paper illustrating how conductance densities of voltage gated channels (fig 2) and the timing of synaptic input with backpropagating action potentials (fig 4) affects membrane voltage trajectories.
Reference:
1 .
Gasparini S,Migliore M (2015) Action Potential Backpropagation
Encyclopedia of Computational Neuroscience
, (Jaeger D:Jung R, ed. pp.133
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Model Information
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Model Type:
Dendrite;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,t;
I A;
I K;
I h;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Dendritic Action Potentials;
Active Dendrites;
Action Potentials;
Synaptic Integration;
Implementer(s):
Migliore, Michele [Michele.Migliore at Yale.edu];
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Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
I Na,t
;
I A
;
I K
;
I h
;
/
GaspariniMigliore2015
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