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A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
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Model Information
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Accession:
149739
This is a two-layer biophysical olfactory bulb (OB) network model to study cholinergic neuromodulation. Simulations show that nicotinic receptor activation sharpens mitral cell receptive field, while muscarinic receptor activation enhances network synchrony and gamma oscillations. This general model suggests that the roles of nicotinic and muscarinic receptors in OB are both distinct and complementary to one another, together regulating the effects of ascending cholinergic inputs on olfactory bulb transformations.
Reference:
1 .
Li G, Cleland TA (2013) A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.
J Neurosci
33
:3037-58
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Olfactory bulb main mitral GLU cell;
Olfactory bulb main interneuron periglomerular GABA cell;
Olfactory bulb main interneuron granule MC GABA cell;
Channel(s):
I Na,p;
I L high threshold;
I T low threshold;
I A;
I M;
I h;
I K,Ca;
I CAN;
I Sodium;
I Calcium;
I Potassium;
I_Ks;
I Cl, leak;
I Ca,p;
Gap Junctions:
Receptor(s):
Nicotinic;
GabaA;
Muscarinic;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Acetylcholine;
Simulation Environment:
NEURON;
MATLAB;
Model Concept(s):
Sensory processing;
Sensory coding;
Neuromodulation;
Olfaction;
Implementer(s):
Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB
for information about:
Olfactory bulb main mitral GLU cell
;
Olfactory bulb main interneuron periglomerular GABA cell
;
Olfactory bulb main interneuron granule MC GABA cell
;
Nicotinic
;
GabaA
;
Muscarinic
;
AMPA
;
NMDA
;
I Na,p
;
I L high threshold
;
I T low threshold
;
I A
;
I M
;
I h
;
I K,Ca
;
I CAN
;
I Sodium
;
I Calcium
;
I Potassium
;
I_Ks
;
I Cl, leak
;
I Ca,p
;
Acetylcholine
;
/
ACh_ModelDB
data
Input
Readme.txt
cadecay.mod
*
Other models using cadecay.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
cadecay2.mod
*
Other models using cadecay2.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Caint.mod
*
Other models using Caint.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Can.mod
*
Other models using Can.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
CaPN.mod
*
Other models using CaPN.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
CaT.mod
*
Other models using CaT.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
GradeAMPA.mod
*
Other models using GradeAMPA.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
GradeGABA.mod
*
Other models using GradeGABA.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
GradNMDA.mod
*
Other models using GradNMDA.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
hpg.mod
*
Other models using hpg.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
kAmt.mod
*
Other models using kAmt.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
KCa.mod
*
Other models using KCa.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
KDRmt.mod
*
Other models using KDRmt.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
kfasttab.mod
*
Other models using kfasttab.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
kM.mod
*
Other models using kM.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
KS.mod
*
Other models using KS.mod:
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
kslowtab.mod
*
Other models using kslowtab.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
LCa.mod
*
Other models using LCa.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
nafast.mod
*
Other models using nafast.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
NaP.mod
*
Other models using NaP.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Naxn.mod
*
Other models using Naxn.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Nicotin.mod
*
Other models using Nicotin.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
nmdanet.mod
*
Other models using nmdanet.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
OdorInput.mod
*
Other models using OdorInput.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Background.hoc
Connect.hoc
GC_def.hoc
GC_save.hoc
*
Other models using GC_save.hoc:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
GC_Stim.hoc
Input.hoc
MC_def.hoc
MC_save.hoc
MC_Stim.hoc
mod_func.c
mosinit.hoc
nrniv.exe.stackdump
OB.hoc
Parameter.hoc
PG_def.hoc
PG_save.hoc
*
Other models using PG_save.hoc:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
PG_Stim.hoc
SaveData.hoc
tabchannels.dat
*
Other models using tabchannels.dat:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Olfactory bulb microcircuits model with dual-layer inhibition (Gilra & Bhalla 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
tabchannels.hoc
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