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Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
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Model Information
Model File
Accession:
150284
"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Reference:
1 .
Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum.
PLoS One
8
:e66811
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Synapse;
Brain Region(s)/Organism:
Striatum;
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
I Na,p;
I Na,t;
I T low threshold;
I A;
I K,Ca;
I CAN;
I Calcium;
I A, slow;
I Krp;
I R;
I Q;
Gap Junctions:
Receptor(s):
Gene(s):
Kv4.2 KCND2;
Kv1.2 KCNA2;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Synaptic Plasticity;
Signaling pathways;
Calcium dynamics;
Multiscale;
Implementer(s):
Mattioni, Michele [mattioni at ebi.ac.uk];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
I Na,p
;
I Na,t
;
I T low threshold
;
I A
;
I K,Ca
;
I CAN
;
I Calcium
;
I A, slow
;
I Krp
;
I R
;
I Q
;
Download the displayed file
/
TimeScales-master
hoc
tau_tables
CVS
tauh_car.txt
*
Other models using tauh_car.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_cat.txt
*
Other models using tauh_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_kas.txt
*
Other models using tauh_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_krp.txt
*
Other models using tauh_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_naf.txt
*
Other models using tauh_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
tauh_nap.txt
*
Other models using tauh_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_cat.txt
*
Other models using taum_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kaf.txt
*
Other models using taum_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kas.txt
*
Other models using taum_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_kir.txt
*
Other models using taum_kir.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_krp.txt
*
Other models using taum_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
taum_naf.txt
*
Other models using taum_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_car.txt
*
Other models using vtau_car.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_cat.txt
*
Other models using vtau_cat.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kaf.txt
*
Other models using vtau_kaf.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kas.txt
*
Other models using vtau_kas.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_kir.txt
*
Other models using vtau_kir.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_krp.txt
*
Other models using vtau_krp.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_naf.txt
*
Other models using vtau_naf.txt:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
vtau_nap.txt
*
Other models using vtau_nap.txt:
A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
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