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Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
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Model Information
Model File
Accession:
150284
"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Reference:
1 .
Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum.
PLoS One
8
:e66811
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Synapse;
Brain Region(s)/Organism:
Striatum;
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
I Na,p;
I Na,t;
I T low threshold;
I A;
I K,Ca;
I CAN;
I Calcium;
I A, slow;
I Krp;
I R;
I Q;
Gap Junctions:
Receptor(s):
Gene(s):
Kv4.2 KCND2;
Kv1.2 KCNA2;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Synaptic Plasticity;
Signaling pathways;
Calcium dynamics;
Multiscale;
Implementer(s):
Mattioni, Michele [mattioni at ebi.ac.uk];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
I Na,p
;
I Na,t
;
I T low threshold
;
I A
;
I K,Ca
;
I CAN
;
I Calcium
;
I A, slow
;
I Krp
;
I R
;
I Q
;
/
TimeScales-master
mod
AMPA.mod
bkkca.mod
*
Other models using bkkca.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
cadyn.mod
caL.mod
*
Other models using caL.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
caL13.mod
*
Other models using caL13.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
caldyn.mod
caltrack.mod
can.mod
*
Other models using can.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
caq.mod
*
Other models using caq.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
car.mod
*
Other models using car.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
cat.mod
*
Other models using cat.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
catrack.mod
GABA.mod
*
Other models using GABA.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)
kaf.mod
*
Other models using kaf.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
kas.mod
*
Other models using kas.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
kir.mod
*
Other models using kir.mod:
A model of optimal learning with redundant synaptic connections (Hiratani & Fukai 2018)
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
krp.mod
*
Other models using krp.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
naf.mod
*
Other models using naf.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
nap.mod
*
Other models using nap.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
NMDA.mod
rubin.mod
skkca.mod
stim.mod
*
Other models using stim.mod:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
vecevent.mod
test_input.py
test_vecstim.py
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