"… We present a new event-driven algorithm to synchronize different neuronal
models, which decreases computational time and avoids superfluous synchronizations.
The algorithm is implemented in the TimeScales framework.
We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum.
The model comprises over a thousand dendritic spines, where the electrical model interacts with the
respective instances of a biochemical model.
Our results show that a multiscale model is able to exhibit changes of synaptic
plasticity as a result of the interaction between electrical and biochemical signaling.
Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum. PLoS One 8:e66811 [PubMed]
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