Synaptic gating at axonal branches, and sharp-wave ripples with replay (Vladimirov et al. 2013)

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The computational model of in vivo sharp-wave ripples with place cell replay. Excitatory post-synaptic potentials at dendrites gate antidromic spikes arriving from the axonal collateral, and thus determine when the soma and the main axon fire. The model allows synchronous replay of pyramidal cells during sharp-wave ripple event, and the replay is possible in both forward and reverse directions.
1 . Vladimirov N, Tu Y, Traub RD (2013) Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study. Eur J Neurosci 38:3435-47 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Dendrite; Connectionist Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Oscillations; Synchronization; Axonal Action Potentials; Place cell/field; Conduction failure; Brain Rhythms;
Implementer(s): Vladimirov, Nikita ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP; Gaba; Glutamate;
// Model of synaptic gating of axonal spikes, using 1 pyramidal cell (PC) synaptically connected with 1 basket cell (IN)
// PC receives two EPSPs, at 100 and 200 ms, in its apical dendrite. The EPSPs trigger spike propagation from the proximal axon collateral (which is tonically active at 200 Hz) 
// into the main axon. The spikes from collateral start to propagate to the PC soma (seen as burst of spikelets and one spike), and to the downstream target of the PC (basket cell).
// The basket cell feeds back to PC soma and inhibits further spiking, thus shutting off spike propagation from proximal axon to the main axon.
// author: Nikita Vladimirov, PhD <>

objref pyr, bask
objref syn1, syn2, syn3
objref Ns1, Ns2, netcon, netconL
pyr = new pyramidalCA1()
bask = new basket()
netconL = new List()

forsec pyr.axonal { nseg *= 9 }
// recording extracellular electrode coordinates, near PC soma:
Ex = 20
Ey = 20
Ez = 0

pyr.shaft syn1 = new AlphaSyn(0.5) // external-> PC dendrite
syn1.tau = 2
syn1.e = 0

bask.soma syn2 = new AlphaSyn(0.5) // PC axon (distal collateral) -> basket cell
syn2.tau = 0.8 

pyr.soma syn3 = new Exp2Syn(0.5) // basket cell -> PC soma
syn3.tau1 = 2
syn3.tau2 = 5
syn3.e = -75

Ns1 = new NetStim()  // EPSP_1, 2.5 nS
Ns1.start = 100
Ns2 = new NetStim()  // EPSP_2, 5 nS
Ns2.start = 200
Ns1.number = Ns2.number = 1

netcon = new NetCon(Ns1,syn1)
netcon.weight = 0.0025
netcon = new NetCon(Ns2,syn1)
netcon.weight = 0.005

pyr.collat[1] netcon = new NetCon(&v(1),syn2)
netcon.weight = 0.0035
netcon.delay = 1

bask.soma netcon = new NetCon(&v(1),syn3)
netcon.weight = 0.050
netcon.delay = 1
objectvar axPulse //pulse generator in the proximal axonal collateral, pulses at 200 Hz
pyr.collat axPulse = new Ipulse1(0.9)
axPulse.amp=0.05 //nA
axPulse.ton = 1 //ms
axPulse.toff = 4 //ms

access pyr.soma