Calcium influx during striatal upstates (Evans et al. 2013)

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Accession:150912
"... To investigate the mechanisms that underlie the relationship between calcium and AP timing, we have developed a realistic biophysical model of a medium spiny neuron (MSN). ... Using this model, we found that either the slow inactivation of dendritic sodium channels (NaSI) or the calcium inactivation of voltage-gated calcium channels (CDI) can cause high calcium corresponding to early APs and lower calcium corresponding to later APs. We found that only CDI can account for the experimental observation that sensitivity to AP timing is dependent on NMDA receptors. Additional simulations demonstrated a mechanism by which MSNs can dynamically modulate their sensitivity to AP timing and show that sensitivity to specifically timed pre- and postsynaptic pairings (as in spike timing-dependent plasticity protocols) is altered by the timing of the pairing within the upstate. …"
Reference:
1 . Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates. J Neurophysiol 110:1631-45 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.2 CACNA1B;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; STDP; Calcium dynamics;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; AMPA; NMDA; Gaba; I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I A, slow; I Krp; I R;
//genesis


/***************************		MS Model, Version 9.1	*********************
**************************** 	      proto.g 	*********************
	Avrama Blackwell 	kblackw1@gmu.edu
	Wonryull Koh		wkoh1@gmu.edu
	Rebekah Evans 		rcolema2@gmu.edu
	Sriram 				dsriraman@gmail.com	
******************************************************************************

*****************************************************************************
*******************************************************************************
	proto.g is called by MScell.g
	it contains one primary routine:  
		make_prototypes
 	and two local routines 
		make_cylind_compartment
		make_spines - this one needs much work
	these are used by the primary and are not intended for external calls
	The primary function, make_prototypes is called exactly once by MSsim.g

******************************************************************************/

include MScell/include_channels.g		// required for calls in make_protypes

//************************ Begin Local Subroutines ****************************

	//********************* Begin function make_cylind_compartment *************
	function make_cylind_compartment
		if (!{exists compartment})
			echo "COMPARTMENT DID NOT EXIST PRIOR TO CALL TO:"
			echo 			"make_cylind_compartment"
			create	compartment compartment
		end

   	addfield compartment position   // add a new field "postion" to store distance to soma
	setfield compartment 		\ 
     		Em         {ELEAK} 	\
      	    initVm     {EREST_ACT} 	\
            inject		0.0 	\
      	    position    0.0
	end
	//************************ End function make_cylind_compartment ************

	//**************************************************************************

//************************ End Local Subroutines ******************************
//*****************************************************************************

//************** Begin function make_prototypes (primary routine) *************
function make_prototypes

  	create neutral /library
  	disable /library
	pushe /library

        make_cylind_compartment

	//********************* create non-synaptic channels in library ************************
       //voltage dependent Na and K channels
	//make functions are in their resepective channel .g files
 	make_NaF_channel	
	make_NaFd_channel
	make_KAf_channel		
	make_KAs_channel	
	make_KIR_channel	
	make_Krp_channel  

       //voltage dependent Ca channels
 	create_CaL12 
	create_CaL13	
	create_CaN
	create_CaR
 	create_CaT

       //Ca dependent K channels
	make_BK_channel
	make_SK_channel
	//********************* End channels in library ************************

end
//************************ End function make_prototypes ***********************