MicrocircuitDB: Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)

Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)

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Accession:151458

We construct an electric compartment model of the striatal medium spiny neuron with a realistic morphology and predict the calcium responses in the synaptic spines with variable timings of the glutamatergic and dopaminergic inputs and the postsynaptic action potentials. The model was validated by reproducing the responses to current inputs and could predict the electric and calcium responses to glutamatergic inputs and back-propagating action potential in the proximal and distal synaptic spines during up and down states.
Reference:
1 . Nakano T, Yoshimoto J, Doya K (2013) A model-based prediction of the calcium responses in the striatal synaptic spines depending on the timing of cortical and dopaminergic inputs and post-synaptic spikes. Front Comput Neurosci 7:119 [PubMed]

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Model Type:	Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:
Cell Type(s):	Neostriatum medium spiny direct pathway GABA cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; I A, slow; I Krp; I R; I Q; I Na, leak; I Ca,p; Ca pump;
Gap Junctions:
Receptor(s):	D1; AMPA; NMDA; Glutamate; Dopaminergic Receptor; IP3;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Reinforcement Learning; STDP; Calcium dynamics; Reward-modulated STDP;
Implementer(s):	Nakano, Takashi [nakano.takashi at gmail.com];

Search NeuronDB for information about: Neostriatum medium spiny direct pathway GABA cell; D1; AMPA; NMDA; Glutamate; Dopaminergic Receptor; IP3; I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; I A, slow; I Krp; I R; I Q; I Na, leak; I Ca,p; Ca pump;

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Nakano_FICN_model

_IVsaveplot.hoc

_paper_condition.hoc

_plot_post02.hoc

_plot_pre_spine.hoc

_saveIVplot.hoc

_timed_input_1AP_spine_post.hoc

_timed_input_Glu.hoc

all_tau_vecs.hoc *

baseline_values.txt

basic_procs.hoc

create_mspcells.hoc *

current_clamp.ses

make_netstims.hoc

msp_template.hoc

netstims_template.hoc *

set_synapse.hoc

set_synapse_caL.hoc

set_synapse_caL13.hoc

set_synapse_can.hoc

set_synapse_caq.hoc

set_synapse_ER.hoc

set_synapse_kir.hoc

set_synapse_naf.hoc

set_synapse_NMDA.hoc

stimxout_jns_sqwave_noinput.dat

synapse_templates.hoc

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