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Model of repetitive firing in Grueneberg ganglion olfactory neurons (Liu et al., 2012)
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Model Information
Model File
Accession:
151817
This model is constructed based on properties of Na+ and K+ currents observed in whole-cell patch clamp recordings of mouse Grueneberg ganglion neurons in acute slices. Two distinct Na+ conductances representing the TTX-sensitive and TTX-resistant currents and one delayed rectifier K+ currrent are included. By modulating the maximal conductances of Na+ currents, one can reproduce the regular, phasic, and sporadic patterns of repetitive firing found in the patch clamp experiments.
Reference:
1 .
Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents.
J Neurophysiol
108
:1318-34
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Olfactory receptor GLU cell;
Grueneberg ganglion neuron;
Channel(s):
I K;
I K,leak;
I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Temporal Pattern Generation;
Action Potentials;
Rebound firing;
Recurrent Discharge;
Olfaction;
Implementer(s):
Liu, Cambrian [camliu at chla.usc.edu];
Search NeuronDB
for information about:
Olfactory receptor GLU cell
;
I K
;
I K,leak
;
I Sodium
;
Download the displayed file
/
GG
readme.txt
code_holder.hoc
elvis.ses
elvism10.ses
elvisp10.ses
graphs.hoc
gui_controller.hoc
hvas.ses
iclamp.hoc
init.hoc
kchannels.ses
leak.ses
mosinit.hoc
*
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load_file("nrngui.hoc") load_file("init.hoc")
