MicrocircuitDB: Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells (Lee et al. 2014)

Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells (Lee et al. 2014)

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Accession:153280

This detailed microcircuit model explores the network level effects of sublayer specific connectivity in the mouse CA1. The differences in strengths and numbers of synapses between PV+ basket cells and either superficial sublayer or deep sublayer pyramidal cells enables a routing of inhibition from superficial to deep pyramidal cells. At the network level of this model, the effects become quite prominent when one compares the effect on firing rates when either the deep or superficial pyramidal cells receive a selective increase in excitation.
Reference:
1 . Lee SH, Marchionni I, Bezaire M, Varga C, Danielson N, Lovett-Barron M, Losonczy A, Soltesz I (2014) Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron 82:1129-44 [PubMed]

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Model Type:	Realistic Network;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell;
Channel(s):	I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):	GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Detailed Neuronal Models; Connectivity matrix; Laminar Connectivity;
Implementer(s):	Bezaire, Marianne [mariannejcase at gmail.com];