Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
neurokit
prototypes
README
camit.p
compt_chop.g *
compt_chop.g.bu *
defaults.g *
defaults.g.bu *
hot *
Neurokit.g *
Neurokit.g.bu *
NEURON.g *
NEURON.g.bu *
newcamit.p
synactivator.g *
synactivator.g.bu *
userprefs.g *
userprefs.g.bu *
xall.g *
xall.g.bu *
xcell_funcs.g *
xcell_funcs.g.bu *
xchannel_funcs.g *
xchannel_funcs.g.bu *
xgeom.g *
xgeom.g.bu *
xgraph_funcs.g *
xgraph_funcs.g.bu *
xicons.g *
xicons.g.bu *
xout_funcs.g *
xout_funcs.g.bu *
xrun.g *
xrun.g.bu *
xselect.g *
xselect.g.bu *
xstartup.g *
xstartup.g.bu *
xtitle.g *
xtitle.g.bu *
                            
// genesis

/**********************************************************************
**
**	DO NOT EDIT THIS FILE IN THE neurokit DIRECTORY!
**
**	Make a copy of this file in every directory that contains .p
**	files and edit the copies, in order to customize neurokit for
**	different simulations. When you run neurokit from other
**	directories, the simulator will look for the local version of
**	userprefs.g, and if it cannot find it there will look for the
**	default in the neurokit directory. This version of userprefs is
**	set up to run the Coarse Asymmetric Mitral cell demo.
**	
**	There are three aspects to customisation :
**	
**    	1	Include the appropriate script files from the /neuron/prototype
**  		directory and from wherever you have defined new prototype
**		elements.
**
**    	2	Invoke the functions that make the prototypes you want for
**		your simulation.
**
**	3	Put your preferences for the user_variables defined in
** 		defaults.g in the copies of this file.
**
**********************************************************************/

echo Using default user preferences!

/**********************************************************************
**
**	1	Including script files for prototype functions
**
**********************************************************************/

/* file for standard compartments */
include compartments 

/* file for Hodgkin-Huxley Squid Na and K channels */
include hhchan 

/* file for Upi's mitral cell channels */
include mitchan 

/* file for Upi's mitral cell synaptic channels */
include mitsynC2 // for now use channelC2 version
// later convert Neurokit to use synchan version
// include mitsyn 

/************************************************************************
**  2	Invoking functions to make prototypes in the /library element
************************************************************************/

/*   To ensure that all subsequent elements are made in the library    */
	pushe /library


	/* Make the standard types of compartments  */

	make_cylind_compartment		/* makes "compartment" */
	make_sphere_compartment		/* makes "compartment_sphere" */
	make_cylind_symcompartment	/* makes "symcompartment" */
	make_sphere_symcompartment	/* makes "symcompartment_sphere" */

	/* These are some standard channels used in .p files */
	make_Na_squid_hh		/* makes "Na_squid_hh" */
	make_K_squid_hh			/* makes "K_squid_hh" */
	make_Na_mit_hh			/* makes "Na_mit_hh" */
	make_K_mit_hh			/* makes "K_mit_hh" */

	/* These are some synaptic channels for the mitral cell */
	make_glu_mit_upi		/* makes "glu_mit_upi" */
	make_GABA_mit_upi		/* makes "GABA_mit_upi" */

	/* returning to the root element */
	pope

/*************************************************************** *******
**
**	3	Setting preferences for user-variables.
**
**********************************************************************/

/* See defaults.g for default values of these. Put your preferred
   values for these in your copy of userprefs in the directory from
   which you are running your simulations. */

user_syntype1 = "glu_mit_upi"
user_syntype2 = "GABA_mit_upi"
user_help = "README"