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Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
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Accession:
154732
"We use a computational model of a hippocampal CA1 pyramidal cell to demonstrate that spine head calcium provides an instantaneous readout at each synapse of the postsynaptic weighted sum of all presynaptic activity impinging on the cell. The form of the readout is equivalent to the functions of weighted, summed inputs used in neural network learning rules. Within a dendritic layer, peak spine head calcium levels are either a linear or sigmoidal function of the number of coactive synapses, with nonlinearity depending on the ability of voltage spread in the dendrites to reach calcium spike threshold. ..."
Reference:
1 .
Graham BP, Saudargiene A, Cobb S (2014) Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity.
Neural Comput
26
:2194-222
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Synaptic Integration;
Implementer(s):
Graham, Bruce [B.Graham at cs.stir.ac.uk];
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GrahamEtAl2014
Cells
Results
readme.html
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Modulation of temporal integration window (Migliore, Shepherd 2002)
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Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
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CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
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run_batsyn.hoc
run_PC.hoc
screenshot1.png
screenshot2.png
screenshot3.png
setup_PC.hoc
synstim.ses
{load_file("run_PC.hoc")}
Simulation Platform