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Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
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Model Information
Model File
Accession:
156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 .
Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum.
J Neurophysiol
111
:836-48
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Neostriatum medium spiny indirect pathway GABA cell;
Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions:
Gap junctions;
Receptor(s):
NMDA;
Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:
GENESIS;
Model Concept(s):
Detailed Neuronal Models;
Parkinson's;
Implementer(s):
Blackwell, Avrama [avrama at gmu.edu];
Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
Neostriatum medium spiny indirect pathway GABA cell
;
NMDA
;
Gaba
;
/
striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g
*
Other models using AddCaSpines.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
addchans.g
*
Other models using addchans.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
addchans.g~
*
Other models using addchans.g~:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
addinput.g
*
Other models using addinput.g:
Calcium influx during striatal upstates (Evans et al. 2013)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
addoutput.g
*
Other models using addoutput.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
addoutput.g~
addoutput_old.g
*
Other models using addoutput_old.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
AddSynapticChannels.g
*
Other models using AddSynapticChannels.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
connectCaChannels.g
*
Other models using connectCaChannels.g:
NMDA subunit effects on Calcium and STDP (Evans et al. 2012)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
DA_files.txt
*
Other models using DA_files.txt:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
globals.g
globals.g~
globals_old.g
globalsCaComp.g
*
Other models using globalsCaComp.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
include_channels.g
*
Other models using include_channels.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScell.g~
MScell.p
*
Other models using MScell.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell_D1.g
*
Other models using MScell_D1.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g
*
Other models using MScell_D2.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScell_D2.g~
MScell_D2_old.g
MScell08.p
*
Other models using MScell08.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell08CM3_D1.p
*
Other models using MScell08CM3_D1.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScell08CM3_D2.p
*
Other models using MScell08CM3_D2.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScell08CM3_old.p
MScellSpine.g
*
Other models using MScellSpine.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScellSpineCtx.g
*
Other models using MScellSpineCtx.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScellSpineTh.g
*
Other models using MScellSpineTh.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScellSyn.g~
*
Other models using MScellSyn.g~:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
MScellSyn_D1.g
*
Other models using MScellSyn_D1.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScellSyn_D2.g
*
Other models using MScellSyn_D2.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
parametersA.g~
parametersA_D1.g
*
Other models using parametersA_D1.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
parametersA_D2.g
*
Other models using parametersA_D2.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
parametersB.g
*
Other models using parametersB.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
parametersC.g
*
Other models using parametersC.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
parametersD.g
*
Other models using parametersD.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
proto.g
*
Other models using proto.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
proto.g~
spines.g
*
Other models using spines.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g
*
Other models using SynParamsCtx.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
SynParamsTh.g
*
Other models using SynParamsTh.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
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