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Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
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Model Information
Model File
Accession:
156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 .
Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum.
J Neurophysiol
111
:836-48
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Neostriatum medium spiny indirect pathway GABA cell;
Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions:
Gap junctions;
Receptor(s):
NMDA;
Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:
GENESIS;
Model Concept(s):
Detailed Neuronal Models;
Parkinson's;
Implementer(s):
Blackwell, Avrama [avrama at gmu.edu];
Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
Neostriatum medium spiny indirect pathway GABA cell
;
NMDA
;
Gaba
;
/
striatalnetwork
MScell
channels
ampa_channel.g
*
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Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
BKKchannel.g
*
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Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
CaL12inact_channel.g
*
Other models using CaL12inact_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
CaL13_channel.g
*
Other models using CaL13_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
CaNinact_channel.g
*
Other models using CaNinact_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
CaR_channel.g
*
Other models using CaR_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
CaT_channel.g
*
Other models using CaT_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
gaba_channel.g
*
Other models using gaba_channel.g:
Calcium influx during striatal upstates (Evans et al. 2013)
NMDA subunit effects on Calcium and STDP (Evans et al. 2012)
K_DR_channel.g
*
Other models using K_DR_channel.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
kAf_chanRE.g
*
Other models using kAf_chanRE.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
kAs_chanRE.g
*
Other models using kAs_chanRE.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
kIR_chanKD.g
*
Other models using kIR_chanKD.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
naF_chanOg.g
*
Other models using naF_chanOg.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
naF_chanOg.g~
nmda_channel.g
*
Other models using nmda_channel.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
SKchannelCaDep.g
*
Other models using SKchannelCaDep.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
synaptic_channel.g
*
Other models using synaptic_channel.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
tabchanforms.g
*
Other models using tabchanforms.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
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