Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at]; Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
// Johannes Hjorth, june 2005
// Sriraman Damodaran, september 2010
// FScell.g - Creates a fast spiking neuron in the library
// make_FS_cell -- Creates the library template for a FS-neuron 

str fsLibraryPath = "/library/fs"


function make_FS_cell (cellpath,pfile)

  readcell {pfile} {cellpath}

// Number of inputs to each compartmenttype

  addfield {cellpath} somaDensityAMPA
  addfield {cellpath} somaDensityNMDA
  addfield {cellpath} somaDensityGABA

  addfield {cellpath} primDensityAMPA
  addfield {cellpath} primDensityNMDA
  addfield {cellpath} primDensityGABA

  addfield {cellpath} secDensityAMPA
  addfield {cellpath} secDensityNMDA
  addfield {cellpath} secDensityGABA

  addfield {cellpath} tertDensityAMPA
  addfield {cellpath} tertDensityNMDA
  addfield {cellpath} tertDensityGABA

// Weights of each input

  addfield {cellpath} somaWeightAMPA
  addfield {cellpath} somaWeightNMDA
  addfield {cellpath} somaWeightGABA

  addfield {cellpath} primWeightAMPA
  addfield {cellpath} primWeightNMDA
  addfield {cellpath} primWeightGABA

  addfield {cellpath} secWeightAMPA
  addfield {cellpath} secWeightNMDA
  addfield {cellpath} secWeightGABA

  addfield {cellpath} tertWeightAMPA
  addfield {cellpath} tertWeightNMDA
  addfield {cellpath} tertWeightGABA

// Set default values for densities

  setfield {cellpath} somaDensityAMPA 1
  setfield {cellpath} somaDensityNMDA 1
  setfield {cellpath} somaDensityGABA 3

  setfield {cellpath} primDensityAMPA 1
  setfield {cellpath} primDensityNMDA 1
  setfield {cellpath} primDensityGABA 3

  setfield {cellpath} secDensityAMPA  1
  setfield {cellpath} secDensityNMDA  1
  setfield {cellpath} secDensityGABA  3

  setfield {cellpath} tertDensityAMPA 1
  setfield {cellpath} tertDensityNMDA 1
  setfield {cellpath} tertDensityGABA 0

// Set default values for synapse weights

  setfield {cellpath} somaWeightAMPA 1.0
  setfield {cellpath} somaWeightNMDA 1.0
  setfield {cellpath} somaWeightGABA 1.0

  setfield {cellpath} primWeightAMPA 1.0
  setfield {cellpath} primWeightNMDA 1.0
  setfield {cellpath} primWeightGABA 1.0

  setfield {cellpath} secWeightAMPA  1.0
  setfield {cellpath} secWeightNMDA  1.0
  setfield {cellpath} secWeightGABA  1.0

  setfield {cellpath} tertWeightAMPA 1.0
  setfield {cellpath} tertWeightNMDA 1.0
  setfield {cellpath} tertWeightGABA 1.0



//************************ Begin Primary Routine ******************************

	//************************ Begin function make_MS_cell *********************
	function make_MS_cell (cellpath,pfile)
         str cellpath,pfile
         echo {cellpath}
 	// function make_MS_cell is the first call from the primary file (MSsim.g). 
	// Note that the first thing it does is to call make_protypes in proto.g. 
	// These prototypes must be made before the call to add_channels. When the
	// function add_channels is modified (as in msv4.0) to no longer add
	// certain channels (such as K13, KRPI & KRPII), then the respective 
	// make_prototypes calls (i.e. make_KRPII_channel should be deleted as 
	// dead code. That is to say that only those channels shown in add_channels 
	// (above) should have a make prototype in function make_prototypes in
	// proto.g
		make_prototypes					//	see proto.g
//		readcell {pfile} {cellpath} -hsolve	//	see MScell.g
              readcell {pfile} {cellpath}
		set_position {cellpath}					// local call
		add_channels {cellpath}					// local call
	//************************ End function make_MS_cell ***********************
//************************ End Primary Routine ********************************