Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
/
striatalnetwork
FScell
channels
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
                            
//genesis
//FScellSyn.g
//This routine takes the FScell without synapses, and adds synapses

include FScell/FScell.g                 //FScell without synapses
include FScell/SynParams.g               //parameters on synaptic channels
include FScell/channels/nmda_channel.g   //function to make nmda channel, either GHK or not, in library
include FScell/channels/synaptic_channel.g // function to make non nmda synaptic channels in library
include FScell/AddSynapticChannels.g	// contains functions to add channels to compartments

function makeFScellSyn (cellname,pfile)
   str cellname,pfile

   str CompName

   make_FS_cell {cellname} {pfile}

	//************* create synaptic channels in library *********
	pushe /library

  	make_synaptic_channel  {AMPAname} {AMPAtau1} {AMPAtau2} {AMPAgmax} {EkAMPA}
  	make_NMDA_channel    {NMDAname} {EkNMDA} {Kmg} {NMDAtau2} {NMDAgmax} {ghk_yesno}
	make_synaptic_channel  {GABAname} {GABAtau1} {GABAtau2} {GABAgmax} {EkGABA}

        pope {cellname}
	
   //********************* end synaptic channels in library **************

      foreach CompName ({el {cellname}/##[TYPE=compartment]}) 
        addNMDAchannel {CompName} {NMDAname} {CA_BUFF_3} {NMDAgmax} {ghk_yesno}
        addSynChannel  {CompName} {AMPAname} {AMPAgmax}
        addSynChannel  {CompName} {GABAname} {GABAgmax}
      end


end