Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at]; Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
AddSynapticChannels.g *
AddSynapticChannels.g~ *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.g~ *
FScell.p *
FScell.p~ *
FScellSyn.g *
FScellSyn.g~ *
include_channels.g *
include_channels.g~ *
proto.g *
proto.g~ *
SynParams.g *
SynParams.g~ *
// This file contains some of the constants defined for the cell
// used by correlatedCellNoise.g and inputManager.g
// correlatedCellNoise.g <-- responsible for the input noise to the cell
// inputManager.g        <-- responsible for the input signal to the cell

// Number of dendrites of each type, and number of compartments in each
int primNum     = 3, secNum     = 6, tertNum     = 12
int primCompNum = 2, secCompNum = 4, tertCompNum = 8

// Relative density of AMPA and GABA 
int somaGluBase  = 1, primGluBase  = 1, secGluBase   = 1, tertGluBase  = 1
int somaGABABase = 3, primGABABase = 3, secGABABase  = 3, tertGABABase = 0

// no GABA on distal dendrites, but increased
// GABA density on proximal dendrites