Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

 Download zip file 
Help downloading and running models
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at]; Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g *
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *

/***************************		MS Model, Version 5.11	**********************
**************************** 	      	K_DR_channel.g 	**********************
Tom Sheehan	703-538-8361
/* AB: replaced q10 with qfactor, which now modifies time constants of channels
* qfactor=0.5 means that channels have been slowed down to produce wider spikes

//************************ Begin Primary Routine ******************************
function make_K_DR_channel
	//********************* Begin Local Variables ******************************
   float xmin = -0.1
   float xmax = 0.05
   int xdivs = 3000
   float x,dx,alpha_m,beta_m,tau_m,m_inf
   int i
   float  qfactor = 0.5   
   float Erev = -0.09    
	//********************* End Local Variables ********************************

 	if ({exists K_DR})
		echo "K_DR tabchannel exists"
 	create tabchannel K_DR 
  	setfield ^ Ek {Erev} 	\
             Gbar 100.0 	\ 
             Ik 0        	\
             Gk 0        	\
             Xpower 1    	\
             Ypower 0    	\
             Zpower 0 

  	call K_DR TABCREATE X {xdivs} {xmin} {xmax}
        dx = (xmax-xmin)/xdivs
        x = xmin
	echo "K_DR increment:" {dx} "V"
   for (i=0;i<={xdivs};i=i+1)

		/*migliore, et,al 1999 */
      alpha_m =1000.0*({exp {-110*(x+0.013)}} )
      beta_m  =1000.0*({exp {-80*(x+0.013)}}) 
      tau_m = {{0.001*50*beta_m/(1e3+alpha_m)}/qfactor}
      m_inf = 1000.0/(1000.0+alpha_m)
      setfield K_DR X_A->table[{i}] {tau_m}
      setfield K_DR X_B->table[{i}] {m_inf}
      x = x+dx

   tweaktau K_DR X 
   setfield K_DR X_A->calc_mode 1 X_B->calc_mode 1
//************************ End Primary Routine ********************************