Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
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striatalnetwork
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g *
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
naF_chanOg.g~
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis

/***************************		MS Model, Version 5.0	*********************
**************************** 	    	SKchannelCaDep.g 		*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
******************************************************************************/


/*************************** SKchannelCaDep.g *************************************
 *	In the original program written by Johanes Hjorth a MatLab routines in 
 * striatum/mspn/table/CaDepCurrents/makeSKCaDepTables.m opened two text (data)
 * files {SKgate.txt & Skinfo.txt and used those to create a set of of text (data)
 * files in striatum/mspn/channels/table/CaDepCurrents"
 * The product of this sequence was then opened by this genesis routine to populate 
 * a set of tabchannels.
 *
 * In the rework by Kai_Du the MatLab files are removed but their product (the data 
 * files) are retained.
 *
 * This revision moves the MatLab calculations to the .g file that is creating
 * the tabchannel and removes the data files. 
 * The comments below are from Hjorth 
		// This is a simplified implementation of the SK channel without voltage
		// dependence. Reference: MaylieBondHersonLeeAdelman2004
		// Fast component has tau=4 ms, slow tau = 70 ms (rough ranges)
 * End Hjorth comments
 
 *************** Tom Sheehan 2/8/09	703-538-8361********************************/

function make_SK_channel

  	int i	= 5
  	int nStep = 1000
  	float SKact = 0.0
  	float CaMax = 0.002
	float theta = 0.0
	float theta_pow = 0.0	
  	float CaMax = 0.002
  	int nStep = 1000
  	float Kd = 0.57e-003
  	float delta = 0.0001
   int y = 1
   float x = 0.0
    		
  	str chanpath = "SK_channel" 
  	
  	pushe /library

  	if (({exists {chanpath}}))
    	return
  	end

  	create  tabchannel {chanpath}
  	setfield	^		Ek  		{-90e-3}		\
					Gbar		0.145e4		\
					Ik			0			\
					Gk			0			\
					Xpower  	0			\
					Ypower  	0			\
					Zpower  	1			

  	call {chanpath} TABCREATE Z {nStep-1} 0 {CaMax} // Creates nCaSteps entries
	
	while(i > 0)
		i = 0
	end
	
	for (i = 0; i < {nStep}; i = i + 1)		 		
  		//let x = Ca; set the value for x 		
  		if(i < 26)
  			x = 0.0
  		else
  			if(y < 51)
  				x = delta
  				y = y + 1
  			else
  				y = 1
  				delta = delta + 0.0001
  			end
  		end 
  		theta = {x/Kd}
  		theta_pow = { pow {theta} 5.4}
  		SKact = theta_pow/{1 + theta_pow}
     	setfield {chanpath} Z_B->table[{i}] {SKact}
		setfield {chanpath} Z_A->table[{i}] {4e-3} // Fast component, tau=4ms
	end		   	  		 			 
  	tweaktau {chanpath} Z
  	pope
end