Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

 Download zip file 
Help downloading and running models
Accession:156260
This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Reference:
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
/
striatalnetwork
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addchans.g~ *
addinput.g *
addoutput.g *
addoutput.g~
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globals.g~
globals_old.g
globalsCaComp.g *
include_channels.g *
MScell.g~
MScell.p *
MScell_D1.g *
MScell_D1.g~
MScell_D1_old.g
MScell_D2.g *
MScell_D2.g~
MScell_D2_old.g
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScell08CM3_old.p
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn.g~ *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA.g~
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
proto.g~
spines.g *
SynParams.g~
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis

/***************************		MS Model, Version 5.5	*********************
**************************** 	  		makeCaChannels.g 		*********************
		Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************
******************************************************************************/

function coupleCaBufferCaChannel(bufferName, compPath, caChannelName)
// called only from function add_uniform_channel in adjust.g
  str bufferName
  str compPath
  str caChannelName

  pushe {compPath}

  if({isa difshell {compPath}/{bufferName}})
    addmsg {caChannelName}GHK {bufferName} INFLUX Ik 
    addmsg {bufferName} {caChannelName}GHK CIN C
  elif({isa Ca_concen {compPath}/{bufferName}})
    addmsg {caChannelName}GHK {bufferName} I_Ca Ik 
    addmsg {bufferName} {caChannelName}GHK CIN Ca  
  end

  pope {compPath}

end

function coupleCaBufferCaChannel1(bufferName, compPath, caChannelName)
// called only from function add_uniform_channel in adjust.g
  str bufferName
  str compPath
  str caChannelName

  pushe {compPath}

  if({isa difshell {compPath}/{bufferName}})
    addmsg {caChannelName}GHK {bufferName} INFLUX Ik 
  elif({isa Ca_concen {compPath}/{bufferName}})
    addmsg {caChannelName}GHK {bufferName} I_Ca Ik 
  end

  pope {compPath}

end

///////////////////////////////////////////////////////////////////////////

function addCaChannel(channelName, compPath, conductance, caBufferName)
// called only from function add_uniform_channel in adjust.g
  str channelName, compPath
  float conductance
  str caBufferName

  pushe {compPath}

    // Copy the GHK part of the channel from library
    copy /library/{channelName}GHK {channelName}GHK

    coupleCaBufferCaChannel {caBufferName} {compPath} {channelName}

    // Couple channel, its GHK object and compartment together
    addmsg {compPath} {channelName}GHK VOLTAGE Vm
    addmsg {channelName}GHK {compPath} CHANNEL Gk Ek
    addmsg {channelName} {channelName}GHK PERMEABILITY Gk

  pope

end