Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)

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This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
1 . Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. J Neurophysiol 111:836-48 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Gap Junctions: Gap junctions;
Receptor(s): NMDA; Gaba;
Simulation Environment: GENESIS;
Model Concept(s): Detailed Neuronal Models; Parkinson's;
Implementer(s): Blackwell, Avrama [avrama at]; Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; NMDA; Gaba;
% This simple function receives a matrix 'spike_times' where each line represents a neuron
% index and each column represents one discrete time step where a spike might have occurred
% or not. If it has a line will be drawn otherwise nothing is done.
% Developed by Rodrigo F. Oliveira 2004-2006
function rasterplot(spike_times)
[n_neurons, t_spk]=size(spike_times);
hold on;
        for i=1:n_neurons
            for t_spk=1:t_spk
                %plot([stimes(i,r,s)],[i],'.','MarkerSize',3)    % use for very heavy rasterplots
                line([spike_times(i,t_spk) spike_times(i,t_spk)],[I I+0.95],'LineWidth',0.7,'Color','k')
set(gca,'XLim',[0 max(max(spike_times))]);
set(gca,'YLim',[1 n_neurons+1]);
title('FS new');
xlabel('Time (s)');
ylabel('Neuron index');