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Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
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This hippocampus model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in containing the unstable spread of excitatory activity in the network.
Hummos A, Franklin CC, Nair SS (2014) Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model.
Hummos A, Nair SS (2017) An integrative model of the intrinsic hippocampal theta rhythm.
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Dentate gyrus granule GLU cell;
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Abstract Izhikevich neuron;
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Dentate gyrus granule GLU cell
Hippocampus CA3 pyramidal GLU cell
Hippocampus CA3 interneuron basket GABA cell
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