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Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
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Model Information
Model File
Accession:
168314
This hippocampus model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in containing the unstable spread of excitatory activity in the network.
Reference:
1 .
Hummos A, Franklin CC, Nair SS (2014) Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model.
Hippocampus
24
:1430-48
[
PubMed
]
2 .
Hummos A, Nair SS (2017) An integrative model of the intrinsic hippocampal theta rhythm.
PLoS One
12
:e0182648
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Dentate gyrus granule GLU cell;
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Abstract Izhikevich neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Acetylcholine;
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Epilepsy;
Storage/recall;
Implementer(s):
Search NeuronDB
for information about:
Dentate gyrus granule GLU cell
;
Hippocampus CA3 pyramidal GLU cell
;
Hippocampus CA3 interneuron basket GABA cell
;
Acetylcholine
;
Gaba
;
Glutamate
;
/
HummosEtAl2014
Outputs
008sepsConnections.txt
008sepsLoc00.txt
*
Other models using 008sepsLoc00.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsLoc01.txt
*
Other models using 008sepsLoc01.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsLoc02.txt
*
Other models using 008sepsLoc02.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsLoc03.txt
*
Other models using 008sepsLoc03.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsLoc04.txt
*
Other models using 008sepsLoc04.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsLoc05.txt
*
Other models using 008sepsLoc05.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsLoc06.txt
*
Other models using 008sepsLoc06.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
008sepsSpikeTime0.txt
008sepsSpikeTime1.txt
008sepsSpikeTime2.txt
008sepsSpikeTime3.txt
008sepsSpikeTime4.txt
008sepsSpikeTime5.txt
008sepsSpikeTime6.txt
009sepsConnections.txt
009sepsLoc00.txt
*
Other models using 009sepsLoc00.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsLoc01.txt
*
Other models using 009sepsLoc01.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsLoc02.txt
*
Other models using 009sepsLoc02.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsLoc03.txt
*
Other models using 009sepsLoc03.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsLoc04.txt
*
Other models using 009sepsLoc04.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsLoc05.txt
*
Other models using 009sepsLoc05.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsLoc06.txt
*
Other models using 009sepsLoc06.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
009sepsSpikeTime0.txt
009sepsSpikeTime1.txt
009sepsSpikeTime2.txt
009sepsSpikeTime3.txt
009sepsSpikeTime4.txt
009sepsSpikeTime5.txt
009sepsSpikeTime6.txt
138OLMoffConnections.txt
138OLMoffLoc00.txt
*
Other models using 138OLMoffLoc00.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffLoc01.txt
*
Other models using 138OLMoffLoc01.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffLoc02.txt
*
Other models using 138OLMoffLoc02.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffLoc03.txt
*
Other models using 138OLMoffLoc03.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffLoc04.txt
*
Other models using 138OLMoffLoc04.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffLoc05.txt
*
Other models using 138OLMoffLoc05.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffLoc06.txt
*
Other models using 138OLMoffLoc06.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
138OLMoffSpikeTime0.txt
138OLMoffSpikeTime1.txt
138OLMoffSpikeTime2.txt
138OLMoffSpikeTime3.txt
138OLMoffSpikeTime4.txt
138OLMoffSpikeTime5.txt
138OLMoffSpikeTime6.txt
139OLMoffConnections.txt
139OLMoffLoc00.txt
*
Other models using 139OLMoffLoc00.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffLoc01.txt
*
Other models using 139OLMoffLoc01.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffLoc02.txt
*
Other models using 139OLMoffLoc02.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffLoc03.txt
*
Other models using 139OLMoffLoc03.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffLoc04.txt
*
Other models using 139OLMoffLoc04.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffLoc05.txt
*
Other models using 139OLMoffLoc05.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffLoc06.txt
*
Other models using 139OLMoffLoc06.txt:
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
139OLMoffSpikeTime0.txt
139OLMoffSpikeTime1.txt
139OLMoffSpikeTime2.txt
139OLMoffSpikeTime3.txt
139OLMoffSpikeTime4.txt
139OLMoffSpikeTime5.txt
139OLMoffSpikeTime6.txt
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