Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)

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Accession:168314
This hippocampus model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in containing the unstable spread of excitatory activity in the network.
Reference:
1 . Hummos A, Franklin CC, Nair SS (2014) Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model. Hippocampus 24:1430-48 [PubMed]
2 . Hummos A, Nair SS (2017) An integrative model of the intrinsic hippocampal theta rhythm. PLoS One 12:e0182648 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Abstract Izhikevich neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Epilepsy; Storage/recall;
Implementer(s):
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Acetylcholine; Gaba; Glutamate;
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HummosEtAl2014
Outputs
008sepsConnections.txt
008sepsLoc00.txt *
008sepsLoc01.txt *
008sepsLoc02.txt *
008sepsLoc03.txt *
008sepsLoc04.txt *
008sepsLoc05.txt *
008sepsLoc06.txt *
008sepsSpikeTime0.txt
008sepsSpikeTime1.txt
008sepsSpikeTime2.txt
008sepsSpikeTime3.txt
008sepsSpikeTime4.txt
008sepsSpikeTime5.txt
008sepsSpikeTime6.txt
009sepsConnections.txt
009sepsLoc00.txt *
009sepsLoc01.txt *
009sepsLoc02.txt *
009sepsLoc03.txt *
009sepsLoc04.txt *
009sepsLoc05.txt *
009sepsLoc06.txt *
009sepsSpikeTime0.txt
009sepsSpikeTime1.txt
009sepsSpikeTime2.txt
009sepsSpikeTime3.txt
009sepsSpikeTime4.txt
009sepsSpikeTime5.txt
009sepsSpikeTime6.txt
138OLMoffConnections.txt
138OLMoffLoc00.txt *
138OLMoffLoc01.txt *
138OLMoffLoc02.txt *
138OLMoffLoc03.txt *
138OLMoffLoc04.txt *
138OLMoffLoc05.txt *
138OLMoffLoc06.txt *
138OLMoffSpikeTime0.txt
138OLMoffSpikeTime1.txt
138OLMoffSpikeTime2.txt
138OLMoffSpikeTime3.txt
138OLMoffSpikeTime4.txt
138OLMoffSpikeTime5.txt
138OLMoffSpikeTime6.txt
139OLMoffConnections.txt
139OLMoffLoc00.txt *
139OLMoffLoc01.txt *
139OLMoffLoc02.txt *
139OLMoffLoc03.txt *
139OLMoffLoc04.txt *
139OLMoffLoc05.txt *
139OLMoffLoc06.txt *
139OLMoffSpikeTime0.txt
139OLMoffSpikeTime1.txt
139OLMoffSpikeTime2.txt
139OLMoffSpikeTime3.txt
139OLMoffSpikeTime4.txt
139OLMoffSpikeTime5.txt
139OLMoffSpikeTime6.txt
                            
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