Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)

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Accession:168314
This hippocampus model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in containing the unstable spread of excitatory activity in the network.
Reference:
1 . Hummos A, Franklin CC, Nair SS (2014) Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model. Hippocampus 24:1430-48 [PubMed]
2 . Hummos A, Nair SS (2017) An integrative model of the intrinsic hippocampal theta rhythm. PLoS One 12:e0182648 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Abstract Izhikevich neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Acetylcholine; Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Epilepsy; Storage/recall;
Implementer(s):
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Acetylcholine; Gaba; Glutamate;
SaveWeights = 1
objref SavedWeights
SavedWeights = new List()
 

 
objref swFile
strdef swFilename
sprint(swFilename, "%s%s%s", outPath, IDstrWeights, "SavedWeights.txt")

if (SaveWeights > 0) {
swFile = new File(swFilename)

swFile.wopen()

swFile.printf("\n")

for s = 0, Syn.count() -1 {
 
  if (Connections.x(s, 5) == 1 || Connections.x(s, 5) == 3) {
  swFile.printf("%g\n", Syn.o(s).W_ampa)
  } else {
   if (Connections.x(s,5) == 0 || Connections.x(s, 5) == 2) {
    swFile.printf("%g\n", Syn.o(s).W_gabaa)
   } else {
   printf("\n ----------- Problem finding connection to record\n")
    }
  }

}
		
swFile.close()
}