Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:168414
" ... To study the mechanisms underlying SCS (Spinal cord stimulation), we constructed a biophysically-based network model of the dorsal horn circuit consisting of interconnected dorsal horn interneurons and a wide dynamic range (WDR) projection neuron and representations of both local and surround receptive field inhibition. We validated the network model by reproducing cellular and network responses relevant to pain processing including wind-up, A-fiber mediated inhibition, and surround receptive field inhibition. ..." See paper for more.
Reference:
1 . Zhang TC, Janik JJ, Grill WM (2014) Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. J Neurophysiol 112:552-67 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Wide dynamic range neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Glutamate; Glycine;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Zhang, Tianhe [tz5@duke.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate; Glycine;
/
ZhangEtAl2014
Foreman SCS
CellTemplates.hoc *
CellTempList.dat *
CellTypeVector.txt *
CellVector.txt *
Connectivities_Surround_ERev_70.xls
Coordinates_Trial.xlsx *
DelayVector.txt *
ERevVector.txt
EX_Cell_filenames.dat *
EX_Cell_filenamesH.dat *
EX_Cell_filenamesM.dat *
EX_Cell_SynapseID.dat *
EX_Cell_Synapses_OneEX_Zone2_SCS.txt *
FromVector.txt *
MakeNetwork.hoc *
MATLAB_Afferent_Spikes_Foreman.mat
MATLAB_Afferent_Spikes_Foreman_Grouped.mat
nrnmech.dll *
RunSim_Foreman.hoc
S_NetStim_SynapseID.dat *
SG_Cell_filenames.dat *
SG_Cell_filenamesH.dat *
SG_Cell_filenamesM.dat *
SG_Cell_Pair_1_Vm.png *
SG_Cell_SynapseID.dat *
SG_Cell_Synapses_OneEX_Multiconn_Glycine.dat *
SG_Cell_Synapses_OneEX_Zone2_SCS.txt *
SGSCS_Cell_filenames.dat *
SGSCS_Cell_filenamesH.dat *
SGSCS_Cell_filenamesM.dat *
SGSCS_Cell_SynapseID.dat *
SGSCS_Cell_Synapses_OneEX_Zone2_SCS.txt *
SGZ2_Cell_Synapses_OneEX_Zone2_SCS.txt *
Shell.hoc
SpikeStatsVector.txt
SpikeTimesVector.txt
SynapseVector.txt *
T_Cell_filenames.dat *
T_Cell_filenamesH.dat *
T_Cell_filenamesM.dat *
T_Cell_SpikeCount.png *
T_Cell_SynapseID.dat *
T_Cell_Synapses_OneEX_Zone2_SCS.txt *
ThresholdVector.txt *
ToVector.txt *
WeightVector.txt
XVector.txt *
YVector.txt *
ZVector.txt *
                            
225
366
371
365
359
371
375
361
367
364
368
364
382
367
365
368
366
371
365
359
371
375
361
367
364
368
364
382
367
365
368
366
371
365
359
371
375
361
367
364
368
364
382
367
365
368
342
355
359
341
348
346
350
337
344
344
336
340
350
346
342
342
355
359
341
348
346
350
337
344
344
336
340
350
346
342
342
355
359
341
348
346
350
337
344
344
336
340
350
346
342
26
26
26
26
26
26
26
26
26
26
26
26
26
26
26
113
107
107
110
109
114
112
109
107
111
109
115
104
110
107
109
109
107
114
110
114
108
109
112
111
108
109
112
109
112
113
107
107
110
109
114
112
109
107
111
109
115
104
110
107
109
109
107
114
110
114
108
109
112
111
108
109
112
109
112
113
107
107
110
109
114
112
109
107
111
109
115
104
110
107
109
109
107
114
110
114
108
109
112
111
108
109
112
109
112
113
107
107
110
109
114
112
109
107
111
109
115
104
110
107
109
109
107
114
110
114
108
109
112
111
108
109
112
109
112
41000