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Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
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Model Information
Model File
Accession:
169457
Python scripts for running NEURON simulations that model a layer V pyramidal cell with certain genetic variants implemented. The genes included are obtained from genome-wide association studies of schizophrenia.
Reference:
1 .
Mäki-Marttunen T, Halnes G, Devor A, Witoelar A, Bettella F, Djurovic S, Wang Y, Einevoll GT, Andreassen OA, Dale AM (2016) Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study.
Biol Psychiatry Cogn Neurosci Neuroimaging
1
:49-59
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I K;
I K,leak;
I M;
I h;
I K,Ca;
I A, slow;
Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.1 SCN1A;
Nav1.7 SCN9A;
Cav3.3 CACNA1I;
Cav1.3 CACNA1D;
Cav1.2 CACNA1C;
Kv2.1 KCNB1;
HCN1;
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Coincidence Detection;
Active Dendrites;
Detailed Neuronal Models;
Schizophrenia;
Implementer(s):
Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I K
;
I K,leak
;
I M
;
I h
;
I K,Ca
;
I A, slow
;
Ca pump
;
/
Maki-MarttunenEtAl2015
models
morphologies
readme.txt
Ca_HVA.mod
*
Other models using Ca_HVA.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Ca_LVAst.mod
*
Other models using Ca_LVAst.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
CaDynamics_E2.mod
*
Other models using CaDynamics_E2.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
epsp.mod
*
Other models using epsp.mod:
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Biochemically detailed model of LTP and LTD in a cortical spine (Maki-Marttunen et al 2020)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer 5 Pyramidal Neuron (Shai et al., 2015)
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
Ih.mod
*
Other models using Ih.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Im.mod
*
Other models using Im.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
K_Pst.mod
*
Other models using K_Pst.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
K_Tst.mod
*
Other models using K_Tst.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
Nap_Et2.mod
NaTa_t.mod
NaTs2_t.mod
SK_E2.mod
*
Other models using SK_E2.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SKv3_1.mod
*
Other models using SKv3_1.mod:
Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
collectscalings.py
collectthresholddistalamps.py
drawfig1.py
drawfig2.py
drawfig3.py
drawfig4.py
drawfig5.py
findthresholddistalamps.py
mutation_stuff.py
mytools.py
runcontrols.py
savesynapselocations.py
scalemutations.py
scalings.sav
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