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Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
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Model Information
Model File
Accession:
169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 .
Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum.
J Neurosci
35
:1149-59
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Axon;
Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Neostriatum medium spiny indirect pathway GABA cell;
Neostriatum fast spiking interneuron;
Channel(s):
I Sodium;
I Potassium;
Kir;
Gap Junctions:
Gap junctions;
Receptor(s):
D1;
D2;
GabaA;
Glutamate;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
GENESIS;
Model Concept(s):
Synchronization;
Detailed Neuronal Models;
Parkinson's;
Implementer(s):
Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
Neostriatum medium spiny indirect pathway GABA cell
;
D1
;
D2
;
GabaA
;
Glutamate
;
I Sodium
;
I Potassium
;
Kir
;
Gaba
;
Glutamate
;
/
DamodaranEtAl2015
FScell
channels
AddSynapticChannels.g
*
Other models using AddSynapticChannels.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
cellMorphology.g
*
Other models using cellMorphology.g:
Gap junction coupled network of striatal fast spiking interneurons (Hjorth et al. 2009)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
errorHandler.g
*
Other models using errorHandler.g:
Gap junction coupled network of striatal fast spiking interneurons (Hjorth et al. 2009)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
FScell.g
*
Other models using FScell.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
FScell.p
*
Other models using FScell.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
FScellSyn.g
*
Other models using FScellSyn.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
include_channels.g
*
Other models using include_channels.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
proto.g
*
Other models using proto.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
SynParams.g
*
Other models using SynParams.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
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