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Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
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Model Information
Model File
Accession:
169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 .
Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum.
J Neurosci
35
:1149-59
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Axon;
Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Neostriatum medium spiny indirect pathway GABA cell;
Neostriatum fast spiking interneuron;
Channel(s):
I Sodium;
I Potassium;
Kir;
Gap Junctions:
Gap junctions;
Receptor(s):
D1;
D2;
GabaA;
Glutamate;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
GENESIS;
Model Concept(s):
Synchronization;
Detailed Neuronal Models;
Parkinson's;
Implementer(s):
Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
Neostriatum medium spiny indirect pathway GABA cell
;
D1
;
D2
;
GabaA
;
Glutamate
;
I Sodium
;
I Potassium
;
Kir
;
Gaba
;
Glutamate
;
/
DamodaranEtAl2015
MScell
channels
unusedChannels
AddCaSpines.g
*
Other models using AddCaSpines.g:
Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
addchans.g
*
Other models using addchans.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
addinput.g
*
Other models using addinput.g:
Calcium influx during striatal upstates (Evans et al. 2013)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
addoutput.g
*
Other models using addoutput.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
addoutput_old.g
*
Other models using addoutput_old.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
AddSynapticChannels.g
*
Other models using AddSynapticChannels.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
connectCaChannels.g
*
Other models using connectCaChannels.g:
NMDA subunit effects on Calcium and STDP (Evans et al. 2012)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
DA_files.txt
*
Other models using DA_files.txt:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
globals.g
globalsCaComp.g
*
Other models using globalsCaComp.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
include_channels.g
*
Other models using include_channels.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell.p
*
Other models using MScell.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell_D1.g
*
Other models using MScell_D1.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell_D1_old.g
*
Other models using MScell_D1_old.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
MScell_D2.g
*
Other models using MScell_D2.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell08.p
*
Other models using MScell08.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell08CM3_D1.p
*
Other models using MScell08CM3_D1.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScell08CM3_D2.p
*
Other models using MScell08CM3_D2.p:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScellSpine.g
*
Other models using MScellSpine.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScellSpineCtx.g
*
Other models using MScellSpineCtx.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScellSpineTh.g
*
Other models using MScellSpineTh.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScellSyn_D1.g
*
Other models using MScellSyn_D1.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
MScellSyn_D2.g
*
Other models using MScellSyn_D2.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
parametersA_D1.g
*
Other models using parametersA_D1.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
parametersA_D2.g
*
Other models using parametersA_D2.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
parametersB.g
*
Other models using parametersB.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
parametersC.g
*
Other models using parametersC.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
parametersD.g
*
Other models using parametersD.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
proto.g
*
Other models using proto.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
spines.g
*
Other models using spines.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g
*
Other models using SynParamsCtx.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
SynParamsTh.g
*
Other models using SynParamsTh.g:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
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