Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

 Download zip file 
Help downloading and running models
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
% This simple function receives a matrix 'spike_times' where each line represents a neuron
% index and each column represents one discrete time step where a spike might have occurred
% or not. If it has a line will be drawn otherwise nothing is done.
% Developed by Rodrigo F. Oliveira 2004-2006
function rasterplot(spike_times)
[n_neurons, t_spk]=size(spike_times);
hold on;
        for i=1:n_neurons
            for t_spk=1:t_spk
                %plot([stimes(i,r,s)],[i],'.','MarkerSize',3)    % use for very heavy rasterplots
                line([spike_times(i,t_spk) spike_times(i,t_spk)],[I I+0.95],'LineWidth',0.7,'Color','k')
set(gca,'XLim',[0 max(max(spike_times))]);
set(gca,'YLim',[1 n_neurons+1]);
title('FS new');
xlabel('Time (s)');
ylabel('Neuron index');