//genesis
//SynParams.g
str AMPAname = "AMPA"
float EkAMPA = 0.0
float AMPAtau1 = 1.1e-3
float AMPAtau2 = 5.75e-3
float AMPAgmax = 0.47e-9 //593e-12 I changed this to make the NMDA/AMPA ratio more like 2.75/1 which is what Ding 2008 finds int corticalstriatal synapses
//more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10
//really should ampa change or NMDA change to get the right ratio? either NMDA=0.94 and ampa=0.47
//or AMPA=0.342 and NMDA = 0.0.684
str GABAname = "GABA"
float GABAtau1 = 0.25e-3 // From Galarreta and Hestrin 1997
float GABAtau2 = 3.75e-3 //(used in Wolfs model)
float EkGABA = -0.060
float GABAgmax = 750e-12 //Modified Koos 2004 (Wolf uses 435e-12)
int GABA2Spine = 0 // = 0, No GABA;
// 1, add GABA to spine head
// 2, add GABA to spine neck
int addCa2Spine = 1 // 0, no ca channels in spine,
//1, yes ca channels in spine (non-synaptic)
int NMDABufferMode = 0 // 1, connect both NMDA and AMPA calcium to NMDA_buffer
// 0, connect only NMDA currents to NMDA_buffer
float useAMPANMDAGHKchannels= 0 // we do not use GHK project for NMDA/AMPA
setclock 0 5e-6 //was 5e-6
// Simulation time step (Second)
setclock 1 2e-5 // time step for ascii output
//setclock 1 1e-4 // time step for graphic output
// parameters for NMDA subunits
// cortex
str subunit = "Thalamus"
float EkNMDA = 0
float Kmg = 3.57
float NMDAtau2 = (155e-3)/2 //thal avg for .42 NR2B and .58 NR2A. (300e-3)/2 (NR2B) (50e-3)/2 (NR2A) 126+29 = 155
float NMDAgmax = 0.94e-9 //NR2A and B from (Moyner et al., 1994 figure 7)
int ghk_yesno=0
str NMDAname = {subunit}
//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines. |