/* K3132 channel
* fills tables with values for alpha and beta and then
* uses tweakalpha to alter the values to A and B
* values for alpha and beta are taken from:
* J. Neurophysiology 82: 2476-2389, 1999
* on page 2478
*
* the functions below convert to physiological units to do the
* calulations and convert back to SI units for the output
*/
/* alpha for the type X gate (activation) */
function K3132ChanAlphaX(voltage)
float voltage = {voltage} * 1e3 /* convert to mV */
float num = {95 - {voltage}}
float denom = {{exp {{-95 + {voltage}} / {-11.8}}} - 1}
/* convert sec to msec */
float act = {{num} / {denom}} * 1e3
return act
end
/* beta for the type X gate (activation) */
function K3132ChanBetaX(voltage)
float voltage = {voltage} * 1e3 /* convert to mV */
float num = 0.025
float denom = {exp {{voltage} / 22.222}}
/* convert sec to msec */
float act = {{num} / {denom}} * 1e3
return act
end
function make_K3132_channel
float Erev = -0.090 /* reversal potential of potassium */
str path = "K3132_channel"
float xmin = -0.1 /* minimum voltage we will see in the simulation */
float xmax = 0.05 /* maximum voltage we will see in the simulation */
float step = 0.005 /* use a 5mV step size */
int xdivs = 30 /* the number of divisions between -0.1 and 0.05 */
int c = 0
create tabchannel {path}
/* make the table for the activation with a range of -100mV - +50mV
* with an entry for ever 5mV
*/
call {path} TABCREATE X {xdivs} {xmin} {xmax}
/* set the alpha and beta for the activation and inactivation */
for(c = 0; c < {xdivs} + 1; c = c + 1)
setfield {path} X_A->table[{c}] {K3132ChanAlphaX {{c * {step}} + xmin}}
setfield {path} X_B->table[{c}] {K3132ChanBetaX {{c * {step}} + xmin}}
end
/* for testing */
// for(c = 0; c < 30; c = c + 1)
// showfield {path} X_A->table[{c}]
// showfield {path} X_B->table[{c}]
// end
setfield {path} Ek {Erev} Xpower 2
/* fill the tables with the values of A and B
* calculated from alpha and beta
*/
tweakalpha {path} X
call {path} TABFILL X 3000 0
setfield {path} X_A->calc_mode 0 X_B->calc_mode 0
end
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