Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
AddSynapticChannels.g *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.p *
FScellSyn.g *
include_channels.g *
proto.g *
SynParams.g *
// This file contains some of the constants defined for the cell
// used by correlatedCellNoise.g and inputManager.g
// correlatedCellNoise.g <-- responsible for the input noise to the cell
// inputManager.g        <-- responsible for the input signal to the cell

// Number of dendrites of each type, and number of compartments in each
int primNum     = 3, secNum     = 6, tertNum     = 12
int primCompNum = 2, secCompNum = 4, tertCompNum = 8

// Relative density of AMPA and GABA 
int somaGluBase  = 1, primGluBase  = 1, secGluBase   = 1, tertGluBase  = 1
int somaGABABase = 3, primGABABase = 3, secGABABase  = 3, tertGABABase = 0

// no GABA on distal dendrites, but increased
// GABA density on proximal dendrites