Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

 Download zip file 
Help downloading and running models
Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
/
DamodaranEtAl2015
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addinput.g *
addoutput.g *
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globalsCaComp.g *
include_channels.g *
MScell.p *
MScell_D1.g *
MScell_D1_old.g *
MScell_D2.g *
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
spines.g *
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis
//MScellSpine.g
//This routine takes the MScell without synapses, and adds synapses

include MScell/MScell.g                 //MScell without synapses
include MScell/SynParamsCtx.g               //parameters on synaptic channels
include MScell/channels/nmda_channel.g   //function to make nmda channel, either GHK or not, in library
include MScell/channels/synaptic_channel.g // function to make non nmda synaptic channels in library
include MScell/AddSynapticChannels.g	// contains functions to add channels to compartments
include MScell/spines.g           //creates spines, puts channels & calcium in spines


function make_MS_cell_spine (cellname,pfile)
   str cellname,pfile

   str CompName

   make_MS_cell {cellname} {pfile}

	//************* create synaptic channels in library *********
	pushe /library

  	make_synaptic_channel  {AMPAname} {AMPAtau1} {AMPAtau2} {AMPAgmax} {EkAMPA}
  	make_NMDA_channel    {NMDAname} {EkNMDA} {Kmg} {NMDAtau2} {NMDAgmax} {ghk_yesno}
	make_synaptic_channel  {GABAname} {GABAtau1} {GABAtau2} {GABAgmax} {EkGABA}


	make_spines

        pope {cellname}
	
   //********************* end synaptic channels in library **************


  //**************SPINES*************************/
    /* these functions needs to be modified.  The following 3 should be optional
        1. allow for putting synaptic channels on spines in library
        2. use new calcium functions and optionally create such in spine
        3. possibly vdep channels in the spines
    */

	//add_spines_evenly  {cellname} spine   310.0e-6    320.0e-6       0.1
	//distal for thal. proximal for cortex
	
	add_spines_evenly  {cellname} spine   0.0e-6    120.0e-6       0.1

end