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Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
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Accession:
182134
"...We use a computational model of hippocampus to investigate possible network mechanisms underpinning normal ripples, pathological ripples, and fast ripples. Our results unify several prior findings regarding HFO mechanisms, and also make several new predictions regarding abnormal HFOs. We show that HFOs are generic, emergent phenomena whose characteristics reflect a wide range of connectivity and network input. Although produced by different mechanisms, both normal and abnormal HFOs generate similar ripple frequencies, underscoring that peak frequency is unable to distinguish the two. Abnormal ripples are generic phenomena that arise when input to pyramidal cells overcomes network inhibition, resulting in high-frequency, uncoordinated firing. In addition, fast ripples transiently and sporadically arise from the precise conditions that produce abnormal ripples. Lastly, we show that such abnormal conditions do not require any specific network structure to produce coherent HFOs, as even completely asynchronous activity is capable of producing abnormal ripples and fast ripples in this manner. These results provide a generic, network-based explanation for the link between pathological ripples and fast ripples, and a unifying description for the entire spectrum from normal ripples to pathological fast ripples."
Reference:
1 .
Fink CG, Gliske S, Catoni N, Stacey WC (2015) Network Mechanisms Generating Abnormal and Normal Hippocampal High-Frequency Oscillations: A Computational Analysis.
eNeuro
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hippocampus CA1 basket cell;
Channel(s):
I Na,t;
I A;
I K;
I h;
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
NMDA;
Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Epilepsy;
Implementer(s):
Fink, Christian G. [cgfink at owu.edu];
Gliske, Stephen [sgliske at umich.edu];
Stacey, William [wstacey at med.umich.edu];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
NMDA
;
Glutamate
;
I Na,t
;
I A
;
I K
;
I h
;
/
hfo_model
mod
ca1ih.mod
*
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High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
ca1ika.mod
*
Other models using ca1ika.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
ca1ikdr.mod
*
Other models using ca1ikdr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
ca1ina.mod
*
Other models using ca1ina.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
caolmw.mod
*
Other models using caolmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
capr.mod
*
Other models using capr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
edrive.mod
*
Other models using edrive.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
exp2synampa.mod
*
Other models using exp2synampa.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
exp2synampapre.mod
*
Other models using exp2synampapre.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
exp2synnmda.mod
*
Other models using exp2synnmda.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
exp2synnmdaperm.mod
*
Other models using exp2synnmdaperm.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
exp2synnmdapre.mod
*
Other models using exp2synnmdapre.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
fvpre.mod
*
Other models using fvpre.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
gap.mod
*
Other models using gap.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
halfgap.mod
*
Other models using halfgap.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
icaolmw.mod
*
Other models using icaolmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
icapr.mod
*
Other models using icapr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
iholmkop.mod
*
Other models using iholmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
iholmw.mod
*
Other models using iholmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
ihpyrkop.mod
*
Other models using ihpyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kahppr.mod
*
Other models using kahppr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kaolmkop.mod
*
Other models using kaolmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kapyrkop.mod
*
Other models using kapyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kcaolmw.mod
*
Other models using kcaolmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kcpr.mod
*
Other models using kcpr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kdrbwb.mod
*
Other models using kdrbwb.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kdrca1.mod
*
Other models using kdrca1.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kdrolmkop.mod
*
Other models using kdrolmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kdrpr.mod
*
Other models using kdrpr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
kdrpyrkop.mod
*
Other models using kdrpyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
na3n.mod
*
Other models using na3n.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
nafbwb.mod
*
Other models using nafbwb.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
nafolmkop.mod
*
Other models using nafolmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
nafpr.mod
*
Other models using nafpr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
nafpyrkop.mod
*
Other models using nafpyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
noisesyn.mod
par_ggap.mod
*
Other models using par_ggap.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
vecevent.mod
*
Other models using vecevent.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Phase response curves firing rate dependency of rat purkinje neurons in vitro (Couto et al 2015)
Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
Synaptic integration by MEC neurons (Justus et al. 2017)
Synthesis of spatial tuning functions from theta cell spike trains (Welday et al., 2011)
Synthesis of spatial tuning functions from theta cell spike trains (Welday et al., 2011)
xtra.mod
*
Other models using xtra.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Direct recruitment of S1 pyramidal cells and interneurons via ICMS (Overstreet et al., 2013)
Direct recruitment of S1 pyramidal cells and interneurons via ICMS (Overstreet et al., 2013)
Retinal ganglion cells responses and activity (Tsai et al 2012, Guo et al 2016)
Survey of electrically evoked responses in the retina (Tsai et al 2017)
aux_fun.inc
*
Other models using aux_fun.inc:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
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