Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

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Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
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SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
load_file("nrngui.hoc")

load_file("Richytrunctest2.hoc")
celsius=24

for i=0,7 soma[i] {
	insert passsd
	g_passsd=1.1231e-05
	erev_passsd=-66.164
	insert Kleaksd
	gkl_Kleaksd=3.2258e-06
	Ra=300
	cm=0.9
	ek=-95
	insert IM
	gbar_IM=0.000075
	insert IMminret
	gbar_IMminret=0 // 0.000075
	insert Ikdrf
	gbar_Ikdrf = 0.0006
	insert Ikdrs
	gbar_Ikdrs = 0.00023
	insert Ika
	gbar_Ika = 0.00025
	insert Nasoma
	gna_Nasoma = 0.0107
	ena=90
	insert Ih
	gkhbar_Ih = 0.00005
	eh=-32
}

for i=0,51 dendrite[i] {
	insert passsd
	g_passsd=1.1231e-05
	erev_passsd=-66.164
	insert Kleaksd
	gkl_Kleaksd=3.2258e-06
	insert IM
	gbar_IM = 0.000075
	insert IMminret
	gbar_IMminret=0 // 0.000075
	insert Ikdrf
	gbar_Ikdrf = 0.0006
	insert Ikdrs
	gbar_Ikdrs = 0.00023
	insert Ika
	gbar_Ika = 0.00025
	Ra=300
	cm=0.9
	ek=-95
	insert cal
	gcalbar_cal = 0.0025
	insert cad
	insert cat
	gbar_cat = 0.00025
	insert kca
	gkbar_kca = 0.00055
	insert Nadend
	gna_Nadend = 0.0117
	ena=90
        if (hD == 1) {
          insert Ih
        }
}

for i=0,4 axon[i] {insert passaxon
	g_passaxon=6.1771e-05
	erev_passaxon=-66.164
	insert Kleakaxon
	gkl_Kleakaxon=1.7742e-05
	insert Ikdrfaxon
	gbar_Ikdrfaxon = 0.0006
	insert Ikdrsaxon
	gbar_Ikdrsaxon = 0.00023
	Ra=300
	cm=0.9
	ek=-95
	insert Naaxon
	gna_Naaxon = 0.0117
	ena=90
} 

/* 
 * Need to call this again, because we have changed Ra and cm,
 * which affects the number of compartments since lambda_f
 * is calculated using these two parameters in each section.
 */
geom_nseg()