MicrocircuitDB: Discharge hysteresis in motoneurons (Powers & Heckman 2015)

Discharge hysteresis in motoneurons (Powers & Heckman 2015)

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Accession:183949

"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
Reference:
1 . Powers RK, Heckman CJ (2015) Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study. J Neurophysiol 114:184-98 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I_AHP; I Calcium; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):	Kv1.2 KCNA2; Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Spike Frequency Adaptation;
Implementer(s):	Powers, Randy [rkpowers at u.washington.edu];