Rhesus Monkey Young and Aged L3 PFC Pyramidal Neurons (Rumbell et al. 2016)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:184497
A stereotypical pyramidal neuron morphology with ion channel parameter combinations that reproduce firing patterns of one young and one aged rhesus monkey L3 PFC pyramidal neurons. Parameters were found through an automated optimization method.
Reference:
1 . Rumbell TH, Draguljic D, Yadav A, Hof PR, Luebke JI, Weaver CM (2016) Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. J Comput Neurosci 41:65-90 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I_AHP; I Cl, leak;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Parameter Fitting; Detailed Neuronal Models; Aging/Alzheimer`s;
Implementer(s):
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; I Na,p; I Na,t; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I_AHP; I Cl, leak;
Column	ParamNumber	Parameter
1		1			dgnaf
2		2			dgnap
3		3			dgkdr
4		4			dgka
5		5			dgk2
6		6			dgar
7		7			dgkm
8		8			dg_pas
9		9			de_pas
10		10			dgkc
11		11			dgkahp
12		12			dphi_cad
13		13			dbeta_cad
14		14			dgcal
15		15			dtmmnaf
16		16			dtmhnaf
17		17			dtmkdr
18		18			dtmkm
19		19			dvsnaf
20		20			dvskdr
21		21			dvskm

Column	FFNumber	Fitness function component
22		1			200ms -160pA:			RF 0-15
23		2							RF 15-30
24		3							RF 150-200
25		4			2s -70pA:			RF 0-15
26		5							RF 150-200
27		6							Rate 15-2015ms, Rate only
28		7			2s +230pA:			RF 0-15
29		8							PP -2,-1
30		9							PP -1,0
31		10							PP 0,1
32		11							PP 1,2
33		12							PP 2,5
34		13							PP 5,10
35		14							PP 10,20
36		15							PP 20,50
37		16							APShape 15-2015ms, -5:10
38		17							APShape 15-2015ms, 10:50
39		18							Rate 15-200ms, FR only
40		19							Rate 15-200ms, CV only
41		20							Rate 200-2015ms, FR only
42		21							Rate 200-2015ms, CV only
43		22							FRfit linear, tot_fr only
44		23							FRfit linear, slope only
45		24							FRfit exp, tot_fr only
46		25							FRfit exp, slope only
47		26			2s +330pA:			RF 0-15
48		27							PP -2,-1
49		28							PP -1,0
50		29							PP 0,1
51		30							PP 1,2
52		31							PP 2,5
53		32							PP 5,10
54		33							PP 10,20
55		34							PP 20,50
56		35							APShape 15-2015ms, -5:10
57		36							APShape 15-2015ms, 10:50
58		37							Rate 15-200ms, FR only
59		38							Rate 15-200ms, CV only
60		39							Rate 200-2015ms, FR only
61		40							Rate 200-2015ms, CV only
62		41							FRfit linear, tot_fr only
63		42							FRfit linear, slope only
64		43							FRfit exp, tot_fr only
65		44							FRfit exp, slope only

66	Total fitness