Rhesus Monkey Young and Aged L3 PFC Pyramidal Neurons (Rumbell et al. 2016)

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Accession:184497
A stereotypical pyramidal neuron morphology with ion channel parameter combinations that reproduce firing patterns of one young and one aged rhesus monkey L3 PFC pyramidal neurons. Parameters were found through an automated optimization method.
Reference:
1 . Rumbell TH, Draguljic D, Yadav A, Hof PR, Luebke JI, Weaver CM (2016) Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. J Comput Neurosci 41:65-90 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I_AHP; I Cl, leak;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Parameter Fitting; Detailed Neuronal Models; Aging/Alzheimer`s;
Implementer(s):
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; I Na,p; I Na,t; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I_AHP; I Cl, leak; 
parameters	min	max	
dgnaf	1e-05	0.5
dgkdr	1e-05	0.5
dgkm	1e-05	0.02
dgka	1e-10	0.02
dgkahp	1e-10	0.01
dgnap	1e-10	0.001
dgcal	1e-10	0.001
dphi_cad	1e-10	52000
dbeta_cad	1e-10	0.01
dtmmnaf	0.05	20
dtmhnaf	0.05	20
dtmkdr	0.05	20
dtmkm	0.05	20
dtmmka	0.05	20
dtmhka	0.05	20
dtmnap	0.05	20
dtmcal	0.5	2
dvsnaf	-40	20
dvskdr	-40	20
dvskm	-40	20
dvska	-40	20
dvsnap	-40	20
dvscal	-40	20