Find models by
Find models for
Find models of
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Download zip file
Help downloading and running models
This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3.
(Click on a link to find other models with that property)
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Sanjay, M [msanjaycmc at gmail.com];
for information about:
Hippocampus CA3 pyramidal GLU cell
Hippocampus CA3 interneuron basket GABA cell
File not selected
<- Select file from this column.