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Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
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" ... In this work, we develop and apply an automated, stepwise method for fitting a neuron model to data with fine spatial resolution, such as that achievable with voltage sensitive dyes (VSDs) and Ca2+ imaging. ... We apply our method to simulated data from layer 5 pyramidal cells (L5PCs) and construct a model with reduced neuronal morphology. We connect the reduced-morphology neurons into a network and validate against simulated data from a high-resolution L5PC network model. ..."
Hay E, Hill S, Schürmann F, Markram H, Segev I (2011) Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties.
PLoS Comput Biol
Hay E, Segev I (2015) Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits.
Mäki-Marttunen T, Halnes G, Devor A, Metzner C, Dale AM, Andreassen OA, Einevoll GT (2018) A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells.
J Neurosci Methods
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
I L high threshold;
I T low threshold;
I A, slow;
NEURON (web link to model);
Maki-Marttunen, Tuomo [tuomo.maki-marttunen at tut.fi];
Metzner, Christoph [c.metzner at herts.ac.uk];
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Neocortex L5/6 pyramidal GLU cell
I L high threshold
I T low threshold
I A, slow
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